Targeted Nanoparticles Open Up Cartilage to Drug Delivery

Summary posted by Meridian on 2/25/2008
Source: In-Pharmatechnologist
Author: Pete Mansell

Researchers from the École Polytechnique Fédérale de Lausanne in Switzerland and the University of Massachusetts in the U.S. have developed polymeric nanoparticles that could be used to administer and maintain drugs in cartilage. The article says that the finding could enable treatment of osteoarthritis, which is currently challenged by the denseness of the extracellular matrix (ECM) of articular cartridge and the lack of vascularized tissue in cartilage. The article says that the nanoparticles, which are made of polypropylene sulphide, are small enough to enter and remain in the ECM. The researchers injected two different sizes of the nanoparticles into the knees of mice and report that “the larger functionalised nanoparticles were generally unable to penetrate the cartilage matrix, whereas the [smaller] particles were small enough to enter the matrix and convert it from a barrier to a reservoir, preventing the rapid release of the nanoparticles and their clearance from the tissue site.” The article can be viewed online at the link below.

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Health And Medical: Diseases
Regions: Europe
Stakeholders: Academia

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our team contact us site map	Targeted Nanoparticles Open Up Cartilage to Drug Delivery Summary posted by Meridian on 2/25/2008 Source: In-Pharmatechnologist Author: Pete Mansell Researchers from the École Polytechnique Fédérale de Lausanne in Switzerland and the University of Massachusetts in the U.S. have developed polymeric nanoparticles that could be used to administer and maintain drugs in cartilage. The article says that the finding could enable treatment of osteoarthritis, which is currently challenged by the denseness of the extracellular matrix (ECM) of articular cartridge and the lack of vascularized tissue in cartilage. The article says that the nanoparticles, which are made of polypropylene sulphide, are small enough to enter and remain in the ECM. The researchers injected two different sizes of the nanoparticles into the knees of mice and report that “the larger functionalised nanoparticles were generally unable to penetrate the cartilage matrix, whereas the [smaller] particles were small enough to enter the matrix and convert it from a barrier to a reservoir, preventing the rapid release of the nanoparticles and their clearance from the tissue site.” The article can be viewed online at the link below. The original article may still be available at www.in-pharmatechnologist.com/news/ng.asp?n=83308-drug-delivery-cartila... As tagged by Meridian Institute: Health And Medical: Diseases Regions: Europe Stakeholders: Academia Related Forums: Health and Medical print format	NDN Home Subscribe Manage Subscription Search News Archives Nanotechnology Quintuples Heating Capacity of Solar Water Heaters -- Renewable Energy Magazine (9/1/2010) Researchers at the University of Rio de Janeiro (UFRJ), Brazil, have developed a solar heating system that uses nanotechnology to heat water to five times the temperature of a conventional system, while also permitting the collector surface area to retain up to 98 percent of heat from solar radiation. [More] Pakistan's Science Minister Attacks Funding Cuts -- SciDev.Net (9/1/2010) The Pakistan government has cuts its funds for the Pakistan Ministry of Science and Technology's 2010-2011 budget by almost half, causing the science minister, Muhammad Azam Khan Swati, to criticize his own government. [More] Nanotechnology: Small wonders -- Nature (9/1/2010) This article takes an in-depth look at the United States National Nanotechnology Initiative (NNI)'s first 10 years - to find out where the money went and what the initiative plans to do next. [More] Nanotech on Farmers' Fields -- Silicon Nutrition (8/31/2010) A plant nutrition study that addresses nano-sized plant nutrients is now available from the Landbouwkundige Uitgeverij G.C. van den Berg (Veenendaal, The Netherlands). [More] More News... Learn how to include these headlines on your own website by clicking here. Please email us if you require text-only versions of the daily emails.